Forscher in Gro\u00dfbritannien haben eine neue, kosteng\u00fcnstige Methode entdeckt, die die Herstellung von Medikamenten beschleunigen k\u00f6nnte. Dabei wird W\u00e4rme statt komplexem Licht oder Elektrochemie verwendet, um wichtige chemische Reaktionen auszul\u00f6sen. Eine Studie der Universit\u00e4t Manchester in Zusammenarbeit mit AstraZeneca zeigte, dass durch Erhitzen von zwei g\u00fcnstigen Chemikalien in einem Standardreaktor eine Vielzahl von chemischen Umwandlungen m\u00f6glich ist. Diese Methode k\u00f6nnte leicht von Milligramm auf 50 Gramm skaliert werden, mit der Aussicht auf weitere Anwendungen im Kilogramm-Bereich und dar\u00fcber hinaus. Im Gegensatz zu modernen Methoden, die oft mit Skalierbarkeitsproblemen zu k\u00e4mpfen haben, erfordert diese Methode keine teuren, spezialisierten Ger\u00e4te. Bei einer 50-Gramm-Skala lieferte die entwickelte Reaktion eines der gew\u00fcnschten Produkte mit einer Ausbeute von 61 Prozent und einer Reinheit von \u00fcber 95 Prozent. Der Prozess f\u00fchrte zu einem sauberen Reaktionsprofil ohne Nebenprodukte, was besonders bemerkenswert ist, da Azo-Initiatoren auch als Elektrophile mit starken Nukleophilen reagieren k\u00f6nnen. Die Forscher hoffen, dass diese einfache Initiierungsmethode in der Industrie und Wissenschaft weit verbreitet werden k\u00f6nnte. Der Artikel wurde in Nature Synthesis ver\u00f6ffentlicht.<\/p>\n","protected":false},"excerpt":{"rendered":"
Forscher in Gro\u00dfbritannien haben eine neue, kosteng\u00fcnstige Methode entdeckt, die die Herstellung von Medikamenten beschleunigen k\u00f6nnte. Dabei wird W\u00e4rme statt […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[454],"tags":[],"class_list":["post-637","post","type-post","status-publish","format-standard","hentry","category-pharmazeutische-nachrichten"],"_links":{"self":[{"href":"https:\/\/www.rathaus-apotheke-kerpen.de\/werbeaktionen\/wp-json\/wp\/v2\/posts\/637","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.rathaus-apotheke-kerpen.de\/werbeaktionen\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.rathaus-apotheke-kerpen.de\/werbeaktionen\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.rathaus-apotheke-kerpen.de\/werbeaktionen\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.rathaus-apotheke-kerpen.de\/werbeaktionen\/wp-json\/wp\/v2\/comments?post=637"}],"version-history":[{"count":1,"href":"https:\/\/www.rathaus-apotheke-kerpen.de\/werbeaktionen\/wp-json\/wp\/v2\/posts\/637\/revisions"}],"predecessor-version":[{"id":647,"href":"https:\/\/www.rathaus-apotheke-kerpen.de\/werbeaktionen\/wp-json\/wp\/v2\/posts\/637\/revisions\/647"}],"wp:attachment":[{"href":"https:\/\/www.rathaus-apotheke-kerpen.de\/werbeaktionen\/wp-json\/wp\/v2\/media?parent=637"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.rathaus-apotheke-kerpen.de\/werbeaktionen\/wp-json\/wp\/v2\/categories?post=637"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.rathaus-apotheke-kerpen.de\/werbeaktionen\/wp-json\/wp\/v2\/tags?post=637"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}